luminex magnetic separator

luminex magnetic plate separator cn-0269-01: r&d systems

PRODUCT FEATURES For performing manual wash procedure with assays containing MagPlex Microparticles Cost effective The Luminex Magnetic Plate Separator is a modified plate magnet intended to separate a 96-well plate of MagPlex Microspheres during assay preparation steps. The side clasps on this magnet have been specially designed to hold a round-bottom plate securely to the magnet, enabling the user to quickly decant it over a waste container. Similar to the method used in an ELISA, this manual plate washing method has been shown to effectively remove nearly all of the supernatant from every well on the plate, with virtually no bead carry-over.

The Luminex Magnetic Plate Separator is a modified plate magnet intended to separate a 96-well plate of MagPlex Microspheres during assay preparation steps. The side clasps on this magnet have been specially designed to hold a round-bottom plate securely to the magnet, enabling the user to quickly decant it over a waste container. Similar to the method used in an ELISA, this manual plate washing method has been shown to effectively remove nearly all of the supernatant from every well on the plate, with virtually no bead carry-over.

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magnetic separators

When handling MagPlex Microspheres, it will often be necessary to separate the magnetic beads from solution. To make these wash steps as easy as possible, Luminex offers two magnetic separators: Magnetic Plate Separator and the Magnetic Tube Separator.

The Luminex Magnetic Plate Separator is a modified plate magnet intended to separate a 96-well plate of MagPlex Microspheres during assay preparation steps. The side clasps on this magnet have been specially designed to hold a round-bottom plate securely to the magnet, enabling the user to quickly decant it over a waste container. Similar to the method used in an ELISA, this manual plate washing method has been shown to effectively remove nearly all of the supernatant from every well on the plate, with virtually no bead carry-over.

The Luminex 1.5 mL Tube Magnetic Separator is intended for a single reaction tube. Typically used in bead coupling reactions, this magnet can quickly separate one mL of MagPlex Microspheres from solution and is a helpful addition to any xMAP bench top.

magplex microspheres, luminex | vwr

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driven by global pandemic, magnetic diagnostics tools from luminex take part in 98% jump in business - magnetics magazine

Your line of business can make a big difference in a pandemic. Just ask the makers of disinfecting wipes and vaccines, or companies like Luminex that make magnetic particles and diagnostic kits for health science laboratories, such as its high-volume 500-analyte assay depicted above.

Driven by growth from the global pandemic, Luminex revenues overall rose 35% in the third quarter of 2020 compared to the same period a year earlier, but its molecular diagnostics sector which encompasses magnetic particles and magnetic separations tools for laboratory analysis nearly doubled. Total revenue company-wide for the three months ended September 30 was $106 million while profitability, bolstered by 60% gross margins, was also higher. Its molecular diagnostics sector, however, jumped 98% to nearly $60 million in revenues.

Based in Austin, Texas,Luminexdevelopsandmanufactures proprietary biological testing technologies, with applications throughout the life-sciences industry. Among these are an extensive line of products that are based on magnetics technology, such as its high-volume 500-analyte assay depicted above.In response to the global outbreak of the novel coronavirus disease, Luminex has developed multiple solutions to enhanceitsofferings to automate and facilitate the detection of SARS-CoV-2 and COVID-19 research.

Im very pleased with the performance of our diversified business during these very challenging times,said Nachum Homi Shamir,chairman,presidentand CEO.Our team continues to execute on our key role in addressing the demands of this pandemic. With strong revenue growth, improved gross margins and continued control over operating expenses, we are seeing healthy profitability and cash flow.

The boom in business will continue into 2021, he projected. Based on our current estimates, we anticipate surpassing our $500 million annual revenue target much sooner than we previously expected, while continuing to build an outstanding company.

As a high-throughput, more comprehensive option for high-complexity labs,the companydevelopeditsNxTAGCoVExtended Panel which can detect SARS-CoV-2 andhasreceivedemergencyuseauthorizationin the US andCanada.Thepanel is a qualitative, multiplex, nucleic acid test for the detection of SARS-CoV-2 in nasopharyngeal swab samples. Designed for use on thecompanysMAGPIXinstrument system, the panel detects three separate gene targets to ensure accurate, reliable results.

MAGPIX is the simplest, most affordable and compact ofthe companysxMAPinstruments.Optimized forhandling magnetic particle assays, thecompact multiplexing unitcanperform up to 50 different tests in a single reaction volume and reads a 96-well plate in just 60 minutes, attributes appreciated by life science labs seeking faster methods for their analyses to meet the demands of Covid-19. It is designed as a simple and easy to use instrument with a smaller footprint.

The companysxMAPbeads come in a variety of formats includingMagPlexwhich are magnetic andMicroPlexnon-magnetic beads.The magnetic microspheres can measure up to 500 targetssimultaneouslyenabling the development of assays which can measure up to 500 different analytes in the same well, as depicted in the image above.Themagneticbeads are universally compatible with allxMAPInstruments.

Similar tothe companys other microspheres, theMagPlexbeadsarecarboxylatedpolystyrene microparticlesthat have been dyed into spectrally distinct sets, or regions, allowing them to be individually identifiedby the instrument.Theuniquely coded beads provide a user an addressable substrate on which to perform multiple bio-analytical reactions in a single well.In the instrument, thebeads pass through a red laser which excites the internal dyes to distinguish the microsphere set. Then, a green laser excites the fluorescent reporter dye to determine the result of the assay.

Among the magnetic bead products areMagPlex-TAG microspheres that allow users to easily design a nucleic acid liquid bead array by hybridizing TAGed primers or probes to the surface of the beads. The particles are dyed into spectrally distinct sets, or regions, allowing them to be individually identified by anxMAPinstrument. Each of the uniquely color-coded beads has a unique 24 base DNA sequence, called an anti-TAG, covalently coupled to its surface. Users can quickly and easily design custom bead arrays simply by adding a complementary TAG sequence to their primers or probes of interest and hybridizing those primers or probes to the anti-TAG sequences on the addressable microsphere.

Other magnetic beads from Luminex include its Avidin-coupled magnetic microspheres to characterize peptides or proteins. Avidin is a protein found in raw egg white. These beads are avidin-coupled paramagnetic microparticles that have been color coded into 100 spectrally distinct sets or regions. Each bead can be used as the substrate on which an assay can be performed. Because each of the beads is uniquely color coded, they can be quickly distinguished by anxMAPinstrument, which allows interrogation of up to 100 different analytes simultaneously from a single sample.

There are several advantages tothe magnetic particles over traditional ones. With the use of amagnetic separator, they can be separated from solution quickly and easily. This improves percent recovery during handling and wash steps and facilitates assay automation.

Luminex offers two magnetic separators, one is a plate separator and the other a tube separator. The plate separatoris a modified plate magnet intended to separate a 96-well plateofMagPlexmicrospheresduring assay preparation steps. The side clasps on this magnet have been specially designed to hold a round-bottom plate securely to the magnet, enabling the user to quickly decant it over a waste container.

The magneticmicrospheres aretypically produced ina concentration of 2.5 million and 12.5 million beads/mlandare packaged in 1mland4mlvials.The company makes two magnetic particle coupling kits for biomolecule assay development and bio-separation, one with bead sizes of 200nm and the other 1m. For more info, seewww.luminexcorp.com.

The value of magnetic particles for life science diagnostics is gaining recognition in biomedical testing laboratories as they race to find new techniques for rapid detection of Covid-19. One company paving the way is Applied BioCode, developer of an innovative Barcoded Magnetic Beads technology, whose SARS-CoV-2 Assay was granted emergency use authorization by the U.S. Food & Drug Administration. []

GE Healthcare is reporting favorable reviews for its new flexible magnetic resonance imaging coils which can dramatically change the way many diagnostic imaging procedures are conducted on patients. For many patients, amagneticresonanceimaging (MRI) scan can []

Some of the most exotic research involving magnetism is sponsored by the U.S. Defense Advanced Research Projects Agency, known as DARPA. One of their programs, literally, boggles the mind as it delves into areas once []

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luminex : r&d systems

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